Article

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

2018-07-13

Abstract excerpt

<h4>SUMMARY</h4> Nurr1, a nuclear receptor essential for the development, maintenance, and survival of midbrain dopaminergic neurons, is a potential therapeutic target for Parkinson’s disease, a neurological disorder characterized by the degeneration of these same neurons. Efforts to identify Nurr1 agonists have been hampered by the recognition that it lacks several classic regulatory elements of nuclear receptor...

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Literature Corpus work: 04d1f194-0de5-5662-9ccd-84606e171c12
DOI: 10.1101/368399

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