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Article

The N-terminal region of Nurr1 (a.a 1-31) is essential for its efficient degradation by the ubiquitin proteasome pathway.

PloS one - 1 Jan 2013

Alvarez-Castelao Beatriz, Losada Fernando, Ahicart Patrícia, Castaño Jose G

Abstract excerpt

NURR1/NR4A2 is an orphan nuclear receptor that is critical for the development and maintenance of mesencephalic dopaminergic neurons and regulates transcription of genes involved in the function of dopaminergic neurons directly via specific NGFI-B response elements (NBRE).and substantial data support a possible role of Nurr1 in the pathogenesis of Parkinson's disease (PD). Here we show that Nurr1 is degraded by...

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Share to Nuclear Receptor Subfamily 4, Group A, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23409108
DOI: 10.1371/journal.pone.0055999
PMCID: PMC3567022

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