Article
The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism.
The Journal of pharmacology and experimental therapeutics - 1 Jun 2018
Hammond Sean L, Popichak Katriana A, Li Xi, Hunt Lindsay G, Richman Evan H, Damale Pranav U, Chong Edwin K P, Backos Donald S, Safe Stephen, Tjalkens Ronald B
Abstract excerpt
The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered. We postulated that the activation of Nurr1 would suppress the activation of glia and thereby protect against loss...
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