Article

Detecting oncogenic selection through biased allele retention in The Cancer Genome Atlas

2020-07-04

Abstract excerpt

<h4>Background</h4> The loss of genetic diversity in segments over a genome (loss-of-heterozygosity, LOH) is a common occurrence in many types of cancer. By analysing patterns of preferential allelic retention during LOH in approximately 10,000 cancer samples from The Cancer Genome Atlas (TCGA), we sought to systematically identify genetic polymorphisms currently segregating in the human population that are prefe...

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Literature Corpus work: 705600f8-d90e-519c-9cb0-c349df44a4d1
DOI: 10.1101/2020.07.03.186593

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