Article
LOHAS: loss-of-heterozygosity analysis suite.
Genetic epidemiology - 1 May 2011
Yang Hsin-Chou, Chang Lun-Ching, Huggins Richard M, Chen Chun-Houh, Mullighan Charles G
Abstract excerpt
Detection of loss of heterozygosity (LOH) plays an important role in genetic, genomic and cancer research. We develop computational methods to estimate the proportion of homozygous SNP calls, identify samples with structural alterations and/or unusual genotypic patterns, cluster samples with close LOH structures and map the genomic segments bearing LOH by analyzing data of genome-wide SNP arrays or customized SNP...
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