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Article

Exonic variants undergoing allele-specific selection in cancers.

BMC medical genomics - 31 May 2021

Li Qiyuan, Zeng Yuanyuan, Wang Janet, Fang Hongkun, Guo Jintao, Yu Liying, Zhong Taoling, Xu Chaoqun, Freedman Matthew, LaFramboise Thomas

Abstract excerpt

BACKGROUND: Allelic imbalance (AI) in tumors is caused by chromosomal and sub-chromosomal gains and losses. RESULTS: We evaluated AI at 109,086 germline exonic SNP loci in four cancer types, and identified a set of SNPs that demonstrate strong tumor allele specificity in AI events. Further analyses demonstrated that these alleles show consistently different frequencies in the cancer population compared to the...

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Identifiers

PMID: 34059054
DOI: 10.1186/s12920-021-00984-1
PMCID: PMC8166126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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