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Article

Loss of heterozygosity: what is it good for?

31 Jul 2015

Abstract excerpt

BACKGROUND: Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour suppressor gene through loss of the wild type allele. METHODS: We analysed 86 ovarian carcinomas for mutations in 980...

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PMID: 26231170
DOI: 10.1186/s12920-015-0123-z

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