Article

Pan-Cancer Analysis Reveals Technical Artifacts in TCGA Germline Variant Calls

2016-12-07

Abstract excerpt

The degree to which germline variation drives cancer development and shapes tumor phenotypes remains largely unexplored, possibly due to a lack of large scale publicly available germline data for a cancer cohort. Here we called germline variants on 9,618 cases from The Cancer Genome Atlas (TCGA) database representing 31 cancer types. We identified batch effects affecting loss of function (LOF) variant calls that c...

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Literature Corpus work: 17580f58-f8f8-5116-a863-3eed96431634
DOI: 10.1101/092163

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