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The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

28 Feb 2022

Abstract excerpt

BACKGROUND: Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer's disease (AD). Recent studies have established that loss of SORL1, as well as mutations in autosomal dominant AD genes APP and PSEN1/2, pathogenically converge by swelling early endosomes, AD's cytopathological hallmark. Acting together with the retromer trafficking complex, SORL1 has been shown to...

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PMID: 35226190
DOI: 10.1007/s00018-022-04182-9

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