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Article

Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele.

Neural plasticity - 1 Jan 2017

Zollo Alen, Allen Zoe, Rasmussen Helle F, Iannuzzi Filomena, Shi Yichen, Larsen Agnete, Maier Thorsten J, Matrone Carmela

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage produces neurotoxic amyloid-beta (Aβ) peptides, which form lethal deposits in the brain. In vivo...

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Source

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Identifiers

PMID: 28634550
DOI: 10.1155/2017/1892612
PMCID: PMC5467336

Genes

SORL1
APP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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