Article

Is <i>SORL1</i> a common genetic target across neurodegenerative diseases?: A multi-ancestry biobank scale assessment

2026-01-30

Abstract excerpt

SORL1, the gene encoding the SORLA protein, has arisen as a potential therapeutic target for Alzheimer’s disease (AD). Studies suggest that restoring SORLA function or its trafficking pathways, particularly the SORLA–retromer recycling system, may offer a promising strategy to slow or halt AD progression. While both rare and common SORL1 variants have been associated with increased AD risk, recent evidence sugges...

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Literature Corpus work: fff04ab3-178a-53b8-bece-559598ac5799
DOI: 10.64898/2026.01.24.26344530

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