Article

The Alzheimer’s disease risk gene <i>SORL1</i> is a regulator of excitatory neuronal function

2025-07-29

Abstract excerpt

<h4>Background</h4> Synaptic dysfunction is an early feature of Alzheimer’s disease (AD) and a significant contributor to cognitive decline and neurodegeneration. Proper localization of proteins involved in pre-and post-synaptic composition is dependent on endosomal recycling and trafficking. Alterations in trafficking complexes, such as retromer, have been shown to impair neuronal synaptic function. The SORL1 g...

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Literature Corpus work: 893d04a2-80f1-5dbf-90ae-88043e7c3865
DOI: 10.1101/2025.07.28.667194

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