Article

The Alzheimer’s gene <i>SORL1</i> is a regulator of endosomal traffic and recycling in human neurons

2021-07-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Loss of the Sortilin-related receptor 1 ( SORL1 ) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have established that loss of SORL1 , as well as mutations in autosomal dominant AD genes APP and PSEN1/2 , pathogenically converge by swelling early endosomes, AD’s cytopathological hallmark. Acting together with the retromer trafficking com...

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Literature Corpus work: c8696d23-d66d-5174-b70d-7ce37a2a2fe1
DOI: 10.1101/2021.07.26.453861

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