Article

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes

2025-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Sortilin-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs target proteins between endocytic and secretory compartments of cells. Mutations in SORL1 , encoding SORLA, are common in individuals suffering from Alzheimer disease (AD) of unknown etiology. Conceptually, characterization of inheritable SORL1 variants associated with AD can provide importa...

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Literature Corpus work: 3ccb1e4d-eea8-5793-bcb6-2c597feb3e62
DOI: 10.1101/2025.04.22.649924

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