Article

Association of circulating proteasome activity with Alzheimer’s pathology and cognitive functions in APOE ε4 carriers

2025-12-15

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Proteasome is a major intracellular protease complex, but the significance of circulating proteasome activity in Alzheimer’s disease (AD) is not well established. Because APOE ε4 is the strongest genetic risk factor for AD, we examined whether plasma proteasome activity is associated with AD-related pathology, neurodegeneration, and cognitive decline, focusin...

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Literature Corpus work: 6fcd8b3f-735c-5048-8b9e-384bb2269b98
DOI: 10.21203/rs.3.rs-8306028/v1

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