Article

Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition

2021-03-29

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele confers the strongest risk for late-onset Alzheimer’s disease (AD) besides age itself, but the mechanism(s) underlying this risk are debated. The critical test of any proposed AD mechanism is whether it leads to effective treatments. We developed a high-throughput assay to identify inhibitors of apoE4-catalyzed polymerization of the amyloid β (Aβ) peptide into neurotoxic fibri...

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Literature Corpus work: 8c31d0cd-cecf-5a43-a578-7bd27a7d8dce
DOI: 10.1101/2021.03.28.437389

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