Article

Imipramine and Olanzapine Block Apoe4-Catalyzed Polymerization of Aβ and Show Evidence of Improving Alzheimer’s Disease Cognition

2022-03-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> The apolipoprotein E ( <italic>APOE</italic> ) ε4 allele confers the strongest risk for late-onset Alzheimer’s disease (AD) besides age itself, but the mechanisms underlying this risk are debated. One hypothesis supported by evidence from multiple labs is that apoE4 binds to the amyloid-β (Aβ) peptide and catalyzes its polymerization into neurotoxic oligomer...

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Literature Corpus work: a3bfd5e3-4df4-5f0b-8472-6abe0ad5c1d8
DOI: 10.21203/rs.3.rs-1428873/v1

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