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Apolipoprotein E polymorphism and oxidative stress in human peripheral blood cells: can physical activity reactivate the proteasome system through epigenetic mechanisms?

2020-08-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Alzheimer’s Disease (AD) is characterised by proteasome activity impairment and oxidative stress, resulting in β-amyloid (Aβ) production/degradation imbalance. Apolipoprotein E (ApoE) is implicated in Aβ clearance, and ApoE ε4 isoform predisposes to AD development. Regular physical activity is known to reduce AD progression. However, the impact of ApoE polymorphi...

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Literature Corpus work
64b86edb-81fd-58ce-a27d-138ecdbec1d6
DOI
10.21203/rs.3.rs-55469/v1
Open publication

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