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Article

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohort

31 Mar 2023

Abstract excerpt

Background Apolipoprotein-E (APOE) ε4 is a major genetic risk factor for Alzheimer’s disease (AD). Current studies, which were mainly based on the clinical diagnosis rather than biomarkers, come to inconsistent conclusions regarding the associations of APOE ε4 homozygotes (APOE ε4/ε4) and cerebrospinal fluid (CSF) biomarkers of AD. In addition, few studies have explored the associations of APOE ε4/ε4 with plasma...

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PMID: 37065463
DOI: 10.3389/fnagi.2023.1119070

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