Article

Whole-genome epigenetic function annotation through sgRNA libraries synthesized by controlled template-dependent elongation

2020-11-05

Abstract excerpt

<title>Abstract</title> <p>Epigenome is the set of DNA-associated proteins or chemical modifications to DNA, which regulates gene expression in processes of development and disease. While current advances have allowed researchers to routinely profile epigenomes from given samples, our understandings of the functions of epigenetic hallmarks are nonspecific at best. Applying CRISPR-screening to genome-widely interr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fc6ff02-f947-5eb0-9ae7-5bd158290e00
DOI: 10.21203/rs.3.rs-100657/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole-genome epigenetic function annotation through sgRNA libraries synthesized by controlled template-dependent elongationDOI 10.21203/rs.3.rs-100657/v1Read

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilitiesSemantic proximity Read

Pooled CRISPR screening at high sensitivity with an empirically designed sgRNA librarySemantic proximity Read

Editing the Epigenome: Reshaping the Genomic Landscape.Semantic proximity Read

Complete guide RNA design for CRISPR-mediated regulation of human long noncoding RNA transcriptionSemantic proximity Read

guidedNOMe-seq quantifies chromatin states at single allele resolution for hundreds of custom regions in parallel.Semantic proximity Read

Massively Targeted Evaluation of Therapeutic CRISPR Off-Targets in CellsSemantic proximity Read

The diploid reference genome of a human embryonic stem cell lineSemantic proximity Read

From profiles to function in epigenomics.Semantic proximity Read

Enhancer RNA transcriptome-wide association study reveals an atlas of pan-cancer susceptibility eRNAsSemantic proximity Read

High-efficiency genomic mapping of chromatin-associated targets with CUT&RUNSemantic proximity Read

RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cellsSemantic proximity Read

Multi-locus CRISPRi targeting with a single truncated guide RNASemantic proximity Read