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Establishment of dopaminergic neuron purification system in mice for the Parkinson’s disease study

2021-03-04

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic (DA) neurons. The key neuropathological hallmarks in the brain of patients with PD are Lewy body (LB) inclusions, consisting of misfolded α-synuclein proteins. Despite extensive efforts, the molecular link between LB inclusions and DA neurodegeneration remains elusive because of the lack of a suit...

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Literature Corpus work
6fc51c69-271a-51ba-b024-37593c993b74
DOI
10.21203/rs.3.rs-296465/v1
Open publication

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