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Article

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation.

Stem cell reports - 11 Oct 2016

Chung Sun Young, Kishinevsky Sarah, Mazzulli Joseph R, Graziotto John, Mrejeru Ana, Mosharov Eugene V, Puspita Lesly, Valiulahi Parvin, Sulzer David, Milner Teresa A, Taldone Tony, Krainc Dimitri, Studer Lorenz, Shim Jae-Won

Abstract excerpt

Parkinson's disease (PD) is characterized by the selective loss of dopamine neurons in the substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A subset of familial PD is linked to mutations in PARK2 and PINK1, which lead to dysfunctional mitochondria-related proteins Parkin and PINK1, suggesting that pathways implicated in these monogenic forms could play a more general role in...

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Identifiers

PMID: 27641647
DOI: 10.1016/j.stemcr.2016.08.012
PMCID: PMC5063469

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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