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Article

Patient-derived three-dimensional cortical neurospheres to model Parkinson’s disease

1 Dec 2022

Abstract excerpt

There are currently no preventive or disease-modifying therapies for Parkinson's Disease (PD). Failures in clinical trials necessitate a re-evaluation of existing pre-clinical models in order to adopt systems that better recapitulate underlying disease mechanisms and better predict clinical outcomes. In recent years, models utilizing patient-derived induced pluripotent stem cells (iPSC) have emerged as attractive...

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PMID: 36454869
DOI: 10.1371/journal.pone.0277532

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