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Modeling High-grade serous ovarian carcinoma using a combination of <i>in vivo</i> electroporation and CRISPR/Cas9 mediated genome editing

2021-03-31

Abstract excerpt

Ovarian cancer remains the most lethal gynecological cancer today. High-grade serous ovarian carcinoma (HGSC) is the most common and lethal type of ovarian cancer and is most frequently diagnosed at advanced stages. Here, we developed a novel strategy to generate somatic ovarian cancer mouse models using a combination of in vivo electroporation and CRISPR/Cas9 mediated genome editing. We mutated tumor suppressor...

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Identifiers and source

Literature Corpus work
bd526769-1b49-597a-8d12-3e6b9d56ef68
DOI
10.1101/2021.03.29.437221
Open publication

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Modeling High-grade serous ovarian carcinoma using a combination of <i>in vivo</i> electroporation and CRISPR/Cas9 mediated genome editingDOI 10.1101/2021.03.29.437221
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