Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational signatures and processes in hepatobiliary cancers.

Nature reviews. Gastroenterology & hepatology - 1 Jun 2022

Zhuravleva Ekaterina, O'Rourke Colm J, Andersen Jesper B

Abstract excerpt

The evolutionary history of hepatobiliary cancers is embedded in their genomes. By analysing their catalogue of somatic mutations and the DNA sequence context in which they occur, it is possible to infer the mechanisms underpinning tumorigenesis. These mutational signatures reflect the exogenous and endogenous origins of genetic damage as well as the capacity of hepatobiliary cells to repair and replicate DNA....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Transformation, Neoplastic
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Source

Identifiers

PMID: 35273358
DOI: 10.1038/s41575-022-00587-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational signatures and processes in hepatobiliary cancers.PMID 35273358Read ↗

Commonalities and differences in the mutational signature and somatic driver mutation landscape across solid and hollow viscus organs.Semantic proximity Read ↗

Mechanisms underlying mutational signatures in human cancers.Semantic proximity Read ↗

Genetic Landscape of Multistep HepatocarcinogenesisSemantic proximity Read ↗

Molecular genomic landscapes of hepatobiliary cancer.Semantic proximity Read ↗

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.Semantic proximity Read ↗

Global patterns of mutational profiles in biliary tract cancer.Semantic proximity Read ↗

Mutational signatures: experimental design and analytical frameworkSemantic proximity Read ↗

Liver cancer in 2013: Mutational landscape of HCC--the end of the beginning.Semantic proximity Read ↗

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer.Semantic proximity Read ↗

Mutational Landscape of Cholangiocarcinoma According to Different Etiologies: A Review.Semantic proximity Read ↗

Mutational signatures in hematological malignancies.Semantic proximity Read ↗

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.