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Article

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

Nature - 22 Jan 2015

Westcott Peter M K, Halliwill Kyle D, To Minh D, Rashid Mamunur, Rust Alistair G, Keane Thomas M, Delrosario Reyno, Jen Kuang-Yu, Gurley Kay E, Kemp Christopher J, Fredlund Erik, Quigley David A, Adams David J, Balmain Allan

Abstract excerpt

Next-generation sequencing of human tumours has refined our understanding of the mutational processes operative in cancer initiation and progression, yet major questions remain regarding the factors that induce driver mutations and the processes that shape mutation selection during tumorigenesis. Here we performed whole-exome sequencing on adenomas from three mouse models of non-small-cell lung cancer, which were...

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Identifiers

PMID: 25363767
DOI: 10.1038/nature13898
PMCID: PMC4304785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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