Article
Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model.
PloS one - 1 Jan 2017
Yang Zuyu, Jia Mingming, Liu Guojing, Hao Huaining, Chen Li, Li Guanghao, Liu Sixue, Li Yawei, Wu Chung-I, Lu Xuemei, Wang Shengdian
Abstract excerpt
With the development of high-throughput genomic analysis, sequencing a mouse primary cancer model provides a new opportunity to understand fundamental mechanisms of tumorigenesis and progression. Here, we characterized the genomic variations in a hepatitis-related primary hepatocellular carcinoma (HCC) mouse model. A total of 12 tumor sections and four adjacent non-tumor tissues from four mice were used for whole...
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