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Article

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.

Hepatology (Baltimore, Md.) - 1 Mar 2018

Riordan Jesse D, Feddersen Charlotte R, Tschida Barbara R, Beckmann Pauline J, Keng Vincent W, Linden Michael A, Amin Khalid, Stipp Christopher S, Largaespada David A, Dupuy Adam J

Abstract excerpt

Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to determine the impact of hepatic injury in an established mouse model of HCC induced by Sleeping Beauty transposon mutagenesis. Chemically induced chronic liver injury...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28961327
DOI: 10.1002/hep.29565
PMCID: PMC5826818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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