Article
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.
Nature communications - 3 Nov 2017
Letouzé Eric, Shinde Jayendra, Renault Victor, Couchy Gabrielle, Blanc Jean-Frédéric, Tubacher Emmanuel, Bayard Quentin, Bacq Delphine, Meyer Vincent, Semhoun Jérémy, Bioulac-Sage Paulette, Prévôt Sophie, Azoulay Daniel, Paradis Valérie, Imbeaud Sandrine, Deleuze Jean-François, Zucman-Rossi Jessica
Abstract excerpt
Genomic alterations driving tumorigenesis result from the interaction of environmental exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is an ideal model to study these interactions. Here, we analyze the whole genomes of 44 new and 264 published liver cancers and we identify 10 mutational and 6 structural rearrangement signatures showing distinct relationships with...
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