Article
Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation
2019-02-28
Abstract excerpt
Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in pre-clinical models of heart failure (HF). However, the mechanisms by which BRD4 promotes pathological myocardial fibrosis remain unclear. Here, we demonstrate that BRD4 functions as an effector of TGF-β signaling to stimulate conversion of quiescent cardiac fibroblasts into Periostin ( Postn )-posit...
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Identifiers and source
- Literature Corpus work
- 6f695191-ba94-5ea9-9d9b-7ba9d828d074
- DOI
- 10.1101/563445