Article

Sertad4 regulates pathological cardiac remodeling.

2026-03-20

Abstract excerpt

Cardiac fibrosis driven by persistent myofibroblast activation is a major contributor to adverse ventricular remodeling and heart failure. Bromodomain and extra-terminal domain (BET) inhibition reduces fibrosis and hypertrophy in preclinical models, but direct targeting of the BET co-activator BRD4 is limited by family homology and potential systemic toxicity. Sertad4 (SERTA domain containing protein 4) is a BRD4-...

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Literature Corpus work: 341d74c0-8f74-5b8f-b7a9-397bb6146bd6
DOI: 10.64898/2026.03.18.708586

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