Article
BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.
Circulation - 15 Dec 2020
Padmanabhan Arun, Alexanian Michael, Linares-Saldana Ricardo, González-Terán Bárbara, Andreoletti Gaia, Huang Yu, Connolly Andrew J, Kim Wonho, Hsu Austin, Duan Qiming, Winchester Sarah A B, Felix Franco, Perez-Bermejo Juan A, Wang Qiaohong, Li Li, Shah Parisha P, Haldar Saptarsi M, Jain Rajan, Srivastava Deepak
Abstract excerpt
BACKGROUND: Gene regulatory networks control tissue homeostasis and disease progression in a cell type-specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how tissue specificity of their function is achieved are poorly understood. BRD4 (bromodomain-containing protein 4), a member of the BET (bromo- and extraterminal domain) family of ubiquitously...
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