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BET Protein-Mediated Transcriptional Regulation in Heart Failure

4 Jun 2021

Abstract excerpt

Heart failure is a complex disease process with underlying aberrations in neurohormonal systems that promote dysregulated cellular signaling and gene transcription. Over the past 10 years, the advent of small-molecule inhibitors that target transcriptional machinery has demonstrated the importance of the bromodomain and extraterminal (BET) family of epigenetic reader proteins in regulating gene transcription in...

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Peptidase Inhibition and Analysis
Protein Degradation and Inhibitors
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34199719
DOI: 10.3390/ijms22116059

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