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BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy

30 Jun 2020

Abstract excerpt

The bromodomain and extraterminal (BET) family comprises epigenetic reader proteins that are important regulators of inflammatory and hypertrophic gene expression in the heart. We previously identified the activation of proinflammatory gene networks as a key early driver of dilated cardiomyopathy (DCM) in transgenic mice expressing a mutant form of phospholamban (PLNR9C) - a genetic cause of DCM in humans. We...

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PMID: 32603312
DOI: 10.1172/jci.insight.138687

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