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Article

BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy

2020-02-10

Abstract excerpt

<h4>ABSTRACT</h4> The bromodomain and extraterminal (BET) family of epigenetic reader proteins are key regulators of pathologic gene expression in the heart. Using mice carrying a human mutation in phospholamban (PLN R9C ) that develop progressive dilated cardiomyopathy (DCM), we previously identified the activation of inflammatory gene networks as a key early driver of DCM. We reasoned that BETs control this in...

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Identifiers and source

Literature Corpus work
0f0601c4-c57d-5a91-a825-aca3aeb77057
DOI
10.1101/2020.02.09.940882
Open publication

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BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated CardiomyopathyDOI 10.1101/2020.02.09.940882
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