Article

A 4-base pair core-enclosing helix in telomerase RNA is essential and binds to the TERT catalytic protein subunit

2020-01-11

Abstract excerpt

<h4>ABSTRACT</h4> The telomerase RNP counters the chromosome end-replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (TERT). Although the majority of the 1157-nt Saccharomyces cerevisiae telomerase RNA, TLC1, is rapidly evolving, the central...

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Literature Corpus work: 6f50e104-7d98-50b9-a680-178bedbfab10
DOI: 10.1101/2020.01.10.902601

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