Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved motif in Tetrahymena thermophila telomerase reverse transcriptase is proximal to the RNA template and is essential for boundary definition.

The Journal of biological chemistry - 26 Jul 2013

Akiyama Benjamin M, Gomez Anastassia, Stone Michael D

Abstract excerpt

The ends of linear chromosomes are extended by telomerase, a ribonucleoprotein complex minimally consisting of a protein subunit called telomerase reverse transcriptase (TERT) and the telomerase RNA (TER). TERT functions by reverse transcribing a short template region of TER into telomeric DNA. Proper assembly of TERT and TER is essential for telomerase activity; however, a detailed understanding of how TERT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleotide Motifs

Share to Protozoan Proteins

Share to RNA, Protozoan

Share to Telomerase

Share to Templates, Genetic

Share to Tetrahymena thermophila

Source

Open in PubMed Open full text

Identifiers

PMID: 23760279
DOI: 10.1074/jbc.M113.452425
PMCID: PMC3724666

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved motif in Tetrahymena thermophila telomerase reverse transcriptase is proximal to the RNA template and is essential for boundary definition.PMID 23760279Read ↗

RNA Binding Domain of Telomerase Reverse TranscriptaseSemantic proximity Read ↗

A 4-base pair core-enclosing helix in telomerase RNA is essential and binds to the TERT catalytic protein subunitSemantic proximity Read ↗

Structure and function of telomerase RNA.Semantic proximity Read ↗

Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.Semantic proximity Read ↗

Template boundary in a yeast telomerase specified by RNA structure.Semantic proximity Read ↗

High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase.Semantic proximity Read ↗

The conserved structure of plant telomerase RNA provides the missing link for an evolutionary pathway from ciliates to humansSemantic proximity Read ↗

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.Semantic proximity Read ↗

Comprehensive structure-function analysis of the core domain of human telomerase RNA.Semantic proximity Read ↗

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanismSemantic proximity Read ↗

Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase.Semantic proximity Read ↗

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.