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Article

Template boundary in a yeast telomerase specified by RNA structure.

Science (New York, N.Y.) - 5 May 2000

Tzfati Y, Fulton T B, Roy J, Blackburn E H

Abstract excerpt

The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which contains a short template for telomeric DNA synthesis. To understand how telomerase RNA participates in mechanistic aspects of telomere synthesis, we studied a conserved secondary structure adjacent to the template. Disruption of this structure caused DNA synthesis to proceed beyond the normal template boundary, resulting in...

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Source

Identifiers

PMID: 10797010
DOI: 10.1126/science.288.5467.863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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