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Article

Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPE

15 Dec 2014

Abstract excerpt

Telomerase catalyzes the addition of nucleotides to the ends of chromosomes to complete genomic DNA replication in eukaryotes and is implicated in multiple diseases, including most cancers. The core enzyme is composed of a reverse transcriptase and an RNA subunit, which provides the template for DNA synthesis. Despite extensive divergence at the sequence level, telomerase RNAs share several structural features...

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PMID: 25512567
DOI: 10.1261/rna.048959.114

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