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Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex

1 Mar 2025

Abstract excerpt

The telomerase complex consists of a protein component (TERT), which has reverse transcriptase activity, and an RNA component (TERC), which serves as a template for telomere synthesis. Evidence is rapidly accumulating regarding the non-canonical functions of these components in both normal or diseased cells. An oligonucleotide-based drug, the first telomerase inhibitor, secured FDA approval in June 2024. We...

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Neutrophil, Myeloperoxidase and Oxidative Mechanisms
RNA regulation and disease
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40025596
DOI: 10.1186/s13578-025-01367-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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