Article

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanism

2026-06-04

Abstract excerpt

Genetic variation at the TERC locus, encoding the telomerase RNA component, is associated with human diseases and lifespan, but a comprehensive functional annotation of this critical non-coding RNA is lacking. Here, we performed saturating variant analysis of TERC in cells and unexpectedly redefine the human telomerase catalytic mechanism. Telomerase is understood to precisely reverse transcribe six TERC templati...

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Literature Corpus work: 68dce40b-22e6-5341-b297-8ea00d3652c5
DOI: 10.64898/2026.06.01.728939

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