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Article

The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes.

Nucleic acids research - 16 Nov 2016

Podlevsky Joshua D, Li Yang, Chen Julian J-L

Abstract excerpt

Telomerase emerged during evolution as a prominent solution to the eukaryotic linear chromosome end-replication problem. Telomerase minimally comprises the catalytic telomerase reverse transcriptase (TERT) and telomerase RNA (TR) that provides the template for telomeric DNA synthesis. While the TERT protein is well-conserved across taxa, TR is highly divergent amongst distinct groups of species. Herein, we have...

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Identifiers

PMID: 27378779
DOI: 10.1093/nar/gkw605
PMCID: PMC5175330

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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