Article

Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells

2017-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Severe cellular sensitivity and aberrant chromosomal rearrangements in response to DNA interstrand crosslink (ICL) inducing agents are hallmarks of Fanconi anemia (FA) deficient cells. These phenotypes have previously been ascribed to inappropriate activity of non-homologous end joining (NHEJ) rather than a direct consequence of DNA ICL repair defects. Here we used chemical inhibitors, RNAi, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f2d6979-b70b-57e8-a917-d9ef22da1dfa
DOI: 10.1101/151472

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cellsDOI 10.1101/151472Read

Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells.Semantic proximity Read

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.Semantic proximity Read

A DNA double strand break repair defect in Fanconi anemia fibroblasts.Semantic proximity Read

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-outSemantic proximity Read

Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.Semantic proximity Read

CCAR1 promotes DNA repair via an unanticipated role in alternative splicingSemantic proximity Read

Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeuticsSemantic proximity Read

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.Semantic proximity Read

Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression as Revealed by a Model Cell Culture SystemSemantic proximity Read

Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining.Semantic proximity Read

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.Semantic proximity Read

Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.Semantic proximity Read