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Article

A DNA double strand break repair defect in Fanconi anemia fibroblasts.

The Journal of biological chemistry - 29 Nov 2002

Donahue Sarah L, Campbell Colin

Abstract excerpt

Fanconi anemia (FA) is a heterogeneous autosomal recessive disease characterized by congenital abnormalities, pancytopenia, and an increased incidence of cancer. Cells cultured from FA patients display elevated spontaneous chromosomal breaks and deletions and are hypersensitive to bifunctional cross-linking agents. Thus, it has been hypothesized that FA is a DNA repair disorder. We analyzed plasmid end-joining in...

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Identifiers

PMID: 12361951
DOI: 10.1074/jbc.M207937200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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