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Article

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.

PloS one - 1 Jan 2013

Kurosawa Aya, Saito Shinta, So Sairei, Hashimoto Mitsumasa, Iwabuchi Kuniyoshi, Watabe Haruka, Adachi Noritaka

Abstract excerpt

Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are two major pathways for repairing DNA double-strand breaks (DSBs); however, their respective roles in human somatic cells remain to be elucidated. Here we show using a series of human gene-knockout cell lines that NHEJ repairs nearly all of the topoisomerase II- and low-dose radiation-induced DNA damage, while it negatively affects survival of...

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Source

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Identifiers

PMID: 23967291
DOI: 10.1371/journal.pone.0072253
PMCID: PMC3743779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.PMID 23967291Read ↗

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Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcsSemantic proximity Read ↗

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Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian CellsSemantic proximity Read ↗

Genetic interactions between BLM and DNA ligase IV in human cells.Semantic proximity Read ↗

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction.Semantic proximity Read ↗

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Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaksSemantic proximity Read ↗

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Impact of DNA ligase IV on the fidelity of end joining in human cells.Semantic proximity Read ↗

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.Semantic proximity Read ↗

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