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Article

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

International journal of molecular sciences - 5 Jul 2023

Shah Ronak, van den Berk Paul C M, Pritchard Colin E J, Song Ji-Ying, Kreft Maaike, Pilzecker Bas, Jacobs Heinz

Abstract excerpt

Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were generated with drug-based selection cassettes in mixed mice backgrounds, leading to a disparity in the interpretation of genotype-related phenotype. We created a...

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Identifiers

PMID: 37446306
DOI: 10.3390/ijms241311129
PMCID: PMC10342586

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