Article
Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining.
Journal of molecular biology - 5 Jun 1998
Escarceller M, Buchwald M, Singleton B K, Jeggo P A, Jackson S P, Moustacchi E, Papadopoulo D
Abstract excerpt
Mutations in genes controlling the correct functioning of the replicative, repair and recombination machineries may lead to genomic instability. A high level of spontaneous chromosomal aberrations amplified by treatment with DNA cross-linking agents is the hallmark of Fanconi anemia (FA), an inhe...
Topics
- Amino Acid Sequence
- Cell Cycle Proteins
- Cell Line
- Chromosome Aberrations
- DNA
- DNA Damage
- DNA Repair
- DNA Replication
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Fanconi Anemia
- Fanconi Anemia Complementation Group Proteins
- Humans
- Molecular Sequence Data
- Nuclear Proteins
- Peptides
- Phenotype
- Protein Serine-Threonine Kinases