Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.

doi:10.1073/pnas.1323649111

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Article

Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014

Felgentreff Kerstin, Du Likun, Weinacht Katja G, Dobbs Kerry, Bartish Margarita, Giliani Silvia, Schlaeger Thorsten, DeVine Alexander, Schambach Axel, Woodbine Lisa J, Davies Graham, Baxi Sachin N, van der Burg Mirjam, Bleesing Jack, Gennery Andrew, Manis John, Pan-Hammarström Qiang, Notarangelo Luigi D

Abstract excerpt

Nonhomologous end-joining (NHEJ) is a key pathway for efficient repair of DNA double-strand breaks (DSBs) and V(D)J recombination. NHEJ defects in humans cause immunodeficiency and increased cellular sensitivity to ionizing irradiation (IR) and are variably associated with growth retardation, microcephaly, and neurodevelopmental delay. Repair of DNA DSBs is important for reprogramming of somatic cells into...

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PMID: 24889605
DOI: 10.1073/pnas.1323649111
PMCID: PMC4066476

Genes

LIG4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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