Article

Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression as Revealed by a Model Cell Culture System

2022-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging and a life expectancy of about 14 years. HGPS is commonly caused by a point mutation in the LMNA gene which codes for lamin A, an essential component of the nuclear lamina. The HGPS mutation alters splicing of the LMNA transcript, leading to a truncated, farnesylated form of lam...

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Literature Corpus work: 227585c8-0bb1-58a7-aa17-d071e05acb9b
DOI: 10.1101/2022.07.18.500488

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