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Article

Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

Molecular cell - 9 Jul 2010

Adamo Adele, Collis Spencer J, Adelman Carrie A, Silva Nicola, Horejsi Zuzana, Ward Jordan D, Martinez-Perez Enrique, Boulton Simon J, La Volpe Adriana

Abstract excerpt

Fanconi anemia (FA) is a complex cancer susceptibility disorder associated with DNA repair defects and infertility, yet the precise function of the FA proteins in genome maintenance remains unclear. Here we report that C. elegans FANCD2 (fcd-2) is dispensable for normal meiotic recombination but is required in crossover defective mutants to prevent illegitimate repair of meiotic breaks by nonhomologous end...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20598602
DOI: 10.1016/j.molcel.2010.06.026

Genes

FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.PMID 20598602Read ↗

C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.Semantic proximity Read ↗

rad-51 downregulation redirects DNA repair and preserves genome stability in FANCD2-deficient Caenorhabditis elegansSemantic proximity Read ↗

Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.Semantic proximity Read ↗

Interdependent and separable functions of <i>C. elegans</i> MRN-C complex members couple formation and repair of meiotic DSBsSemantic proximity Read ↗

NHJ-1 Is Required for Canonical Nonhomologous End Joining in Caenorhabditis elegans.Semantic proximity Read ↗

Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation.Semantic proximity Read ↗

NHJ-1 regulates canonical non-homologous end joining in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates.Semantic proximity Read ↗

RTEL-1 enforces meiotic crossover interference and homeostasis.Semantic proximity Read ↗

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.Semantic proximity Read ↗

Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.Semantic proximity Read ↗

DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.Semantic proximity Read ↗

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